The fire broke out at around 6.45am on Wednesday morning in Philadelphia.
The building where the fire broke out was originally a house that had been converted into two apartments.
Fire officials confirmed that the fire was fatal, but did not specify how many victims there were.
A 36-year-old man was also rushed to hospital with second-degree burns to his legs. He is reported to be in a serious – but stable – condition.
The cause of the fire has not yet been revealed but is under investigation.
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